Ozempic Side Effects: The Secret Doctors Aren’t Telling You About Microdosing!

Tired of harsh side effects from Ozempic or Wegovy? Discover the breakthrough secret that could change your weight loss journey—sublingual semaglutide microdosing!

In this powerful short pulled from The Partovi Effect, Dr. Ryan and Mrs. Madi Partovi reveal why most side effects from weight loss medications aren’t just “bad luck”—they’re a sign your body is getting too much, too fast. Learn how sublingual (under the tongue) microdosing bypasses the harsh digestive process, delivers results with fewer side effects, and helps your body’s own appetite and insulin regulation kick in.

You’ll get insider details on:
Why side effects happen—and what it means for your dose
How sublingual delivery is a game-changer for absorption and comfort
Why needles and big pills may not be your best option
Real patient stories and the science behind gentle, effective weight loss
Are you ready to explore a smarter, safer way to reach your health goals?

Let us know in the comments—what’s your biggest challenge with weight loss medications?

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The contents of this podcast are for educational purposes only and do not constitute medical advice. Talk to your medical professional before starting any new treatment.

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Transcript

  📍  📍 And not that these are toxins, but basically that's the idea here is that, if you can use a low enough dose, I.

It's still gonna be doing beneficial things, but you're not gonna overshoot and have all the side effects, which are the side effects really come not because it's oh, this medication in certain people are definitely gonna get these side effects regardless of the dose. No, the side effects are indication that you are at too high of a dose or at least too high of a dose for your body right now.

Because this medication is so potent, just like naltrexone, right? You can act, oh, and I didn't finish explaining that with Naltrexone, you get a little bit of naltrexone and actually improves your body's own production of opioids. So it's an open question. I mean I, I'd be curious to see if, get some research on this front in the next five, 10 years, whether it might be possible that, with these low doses with the microdosing, we may actually see some of the body's own.

It is body's own appetite regulation and insulin sensitivity regulation and that kind of stuff actually kick in and up regulate as a result of the low dose GLP ones. I think it's very likely. Yeah, so some people do, they try to do microdosing with injectables just to. Only a few clicks with the injections.

And there's this whole trend about click charts and how to dial tiny doses with the pins. But we think sublingual is just a lot more approachable. A lot of people don't like needles. A lot of people don't want to be injecting anything on a regular basis. And the sublingual route is definitely one we've used for a long time with a lot of different hormones and certain nutrients.

But the delivery method that we now have available for these peptides, 'cause historically, again, peptides, we couldn't do peptides orally at all, even sublingually, because the absorption wasn't fast enough that you were going to, the peptide would basically get into the gut and it would just get digested.

So now we have these new sublingual carriers and vehicles that will allow that absorption and it's faster. We'll talk more about that in a minute, but 

yeah, so we're transitioning into why under the tongue. Okay. And I think a lot of our listeners, a lot of our community are really curious.

Semaglutide isn't normally just a pill that you swallow, although, I think there once existed like a big old pill that you swallowed that you had to take in a special way. So what is the advantage of sublingual microdosing versus just taking a small pill or a tiny injection?

Yeah, so that's a great question. The main issue, like I mentioned, was the peptide drugs are really notoriously hard to absorb if you swallow them. So if you swallow semaglutide, your stomach and intestines are just gonna destroy most of it, and very little of it will get in the bloodstream. So even under ideal conditions, the oral semaglutide, you're only gonna get maybe 0.4 to 1% of it to get digested.

So that means, greater than 99% of it is never even gonna get absorbed. And so that's why they had to create that oral tablet Rybelsus that's 14 milligrams. Yes, 14 milligrams taken daily to get a similar effect as the one milligram weekly shot. So they had to overwhelm the gut barriers with brute force and this absorption enhancer in the pill in order to get it through.

Wow, that's almost a hundred milligrams a week.

Yeah. Yeah. It, points to how inefficient the gut absorption is ultimately for that particular molecule. And that's under perfect conditions, empty stomach, if we tried to microdose by swallowing orally, tiny amounts, it would be too low to matter. You'd be really absorbing practically nothing but sublingual under the tongue gives this an interesting option because when you put a drug under the tongue or even inside the cheek, you can cheek it, it can diffuse through the mucus membranes there and get directly into the bloodstream without going through the stomach and the liver first.

So we, we say it bypasses both the digestive destructive process as well as what's called first pass metabolism, which is when it goes first through the liver once, and it, a lot of it gets inactivated. By doing this sublingual, you get a much smaller amount of the drug, but it's still, it can have a much more powerful effect because it's reaching through the circulation intact.

So brands, it's like finding a side door, okay? Instead of like root force going through the front door where there's like a bunch of security guards and the security guards are like stomach, acid and enzymes and they're there waiting to beat you up. 

Yeah. 

Okay. So under the tongue it sneaks into the bloodstream more directly?

Yeah, in a way it is like a workaround. That's a good, that's a good analogy.